Hallelujah moments : tales of drug discovery /
by Eugene H. Cordes.
- 2nd.
- New York, NY : Oxford University Press, 2020
- 1 online resource (336, pages) : color illustrations.
https://www.universitypressscholarship.com/
Includes bibliographical references and index
1. Seduced by Drug discovery -- 2. The small molecules of life -- 3. Proteins : molecular wonders in three dimensions -- 4. Proteins perform multiple functions : enzymes, receptors, ion channel proteins -- 5. Drug discovery and development : the road from an idea to promoting human health -- 6. Finasteride : the Gary and Jerry show -- 7. Basic research, snake venoms, and ACE inhibitors : Ondetti, Cushman, and Patchett Get -- 8. Statins : Protection against heart attacks and strokes—Hallelujah! -- 9. The perils of primaxin -- 10. Avermectins : Molecules of life battle parasites -- 11. Fludalanine : nice try but no Hallelujah ---- 12. Diabetes breakthroughs : Januvia and Janumet
Drug discovery in the pharmaceutical industry has important consequences for the health and wellbeing of people everywhere. However, the general public knows little about the paths through which basic research findings are translated into products that protect or restore human health: the route from the laboratory bench to the bedside. In Hallelujah Moments, Eugene Cordes reveals how some of the most important and influential drugs have been brought into the practice of clinical medicine through the wit and determination of scientists in academia and industry. He shares his firsthand knowledge of the drug-discovery world, having spent a long and distinguished career in both the academic and industrial settings. These tales are “adventure stories,” and they trace the route of important drugs like Januvia, Primaxin, Capoten, and Zocor from concept to the clinic. Cordes shows us the dynamic and critical thinking needed to create a drug that meets important health needs. These are human stories of imagination, risk–taking, problem–solving, and perseverance. Written accessibly for a non-scientist audience, Hallelujah Moments provides insights into the fascinating world of drug discovery like never before.